Magnesium chloride in acute and chronic diseases

by Raul Vergini, MD

Raul Vergini wrote: Hi to all, following a request by Johnatan Light, ND, L.Ac., I am sending a copy (slightly edited) of my article about Magnesium Chloride Therapy published on Townsend Letter for Doctor in November 1992. This is the only work I have in English. I published also a book about this matter in 1994, but it is in Italian. I hope this can interest and help someone: MAGNESIUM CHLORIDE IN ACUTE AND CHRONIC DISEASES by Raul Vergini, MD.

Back in 1915, a French surgeon, Prof. Pierre Delbet, MD, was looking for a solution to cleanse wounds, because he had found that the traditional antiseptic solutions actually mortified tissues and facilitated the infection instead of preventing it. He tested several mineral solutions and discovered that a Magnesium chloride solution was not only harmless for tissues, but it had a great effect over leucocytic activity and phagocytosis; so it was perfect for external wounds treatment.  Dr. Delbert performed a lot of 'in vitro' and 'in vivo' experiments with this solution and he became aware that it was good not only for external applications , but it was also a powerful immuno- stimulant if taken by injections or even by mouth. He called this effect 'cytophilaxis'. In some 'in vivo' experiments it was able to increase phagocytosis rate up to 300%.   Dr. Delbert serendipitously discovered that this oral solution had a tonic effect on many people and so became aware that the Magnesium Chloride had an effect on the whole organism. In a brief time, he received communications of very good therapeutic effects of this 'therapy' from people that were taking Magnesium Chloride for its tonic properties and who were suffering from various ailments. Prof. Delbet began to closely study the subject and verified that Magnesium Chloride solution was a very good therapy for a long list of diseases.

He obtained very good results in : colitis, angiocholitis and cholecystitis in the digestive apparatus: Parkinson's Disease, senile tremors and muscular cramps in the nervous system; acne; eczema, psoriasis, warts , itch of various origins and chilblains in the skin. There was a strengthening of hair and nails, a good effect on diseases typical of the aged (impotency, prostatic hypertrophy, cerebral and circulatory troubles and on diseases of allergic origin (hay-fever, asthma, urticaria and anaphylactic reactions).  Then Prof. Delbet began to investigate the relationship between Magnesium and Cancer. After a lot of clinical and experimental studies , he found that Magnesium Chloride had a very good effect on prevention of cancer and found it was able to cure several precancerous conditions: leucoplasia, hyperkeratosis, chronic mastitis, etc.  Epidemiological studies confirmed Delbet's views and demonstrated regions with soil more rich in magnesium had less cancer incidence and vice versa. In experimental studies, the Magnesium Chloride solution was also found to slow down the course of cancer in laboratory animals.

Prof. Delbet wrote two books, "Politique Preventive du Cancer" (1944) and "L'Agriculture et la Sante" (1945), in which he stated his ideas about cancer prevention and a better living. The first is a well documented report of all his studies on Magnesium Chloride. In 1943 another French doctor, A. Neveu, MD , used the Magnesium Chloride solution in a case of diptheria to reduce the risks of anaphylactic reaction due to the anti-diphteric serum that he was ready to administer. To his great surprise , when the next day the laboratory results confirmed the the diagnosis of diphteria, the little girl was completely cured , before he could use the serum. He credited the immuno-stimulant activity to the solution for this result, and he tested it in some other diptheric patients. All the patients were cured in a very short time (24-48 hours), with no after-effects.

Magnesium Chloride has no direct effect on bacteria (i.e. it is not an antibiotic), Neveu thought that its action was a specific, immuno- enhancing, so it could be useful , in some cases of poliomyelitis and had the same wonderful results. He was very excited and tried to divulge the therapy, but he ran into a wall of hostility and obstructionism from 'Official Medicine'. Neither Neveu or Delbet (who was a member of the Academy of Medicine) was able to diffuse Neveu's extraordinary results. The opposition was total: Professors of Medicine, Medical Peer-Reviews, the Academy itself, all were against the two doctors. "Official Medicine" saw in Magnesium Chloride Therapy a threat to its new and growing business: vaccinations.

Dr. Neveu wasn't discouraged by this and continued to test this therapy in a wide range of diseases. He obtained very good results in: pharyngitis, tonsillitis, hoarseness, common cold, influenza, asthma, bronchitis, broncho-pneumonia, pulmonary emphysema, "children diseases" (whooping-cough, measles, rubella, mumps , scarlet fever...), alimentary and professional poisonings, gastroenteritis, boils, abscesses, erysipelas, whitlow, septic pricks (wounds), puerperal fever and osteomyelitis. But the indications for Magnesium Chloride therapy don't end here.

In more recent years other physicians (I am among these) have verified many of Delbet's and Neveu's applications and have tried the therapy in other pathologies: asthmatic acute attack, shock , tetanus (for these the solution is administered by intravenous injection); herpes zoster, acute and chronic conjunctivitis, optic neuritis, rheumatic diseases, many allergic diseases, spring-asthenia and Chronic Fatigue Syndrome (even in cancer it can be a useful adjuvant). The preceding lists of ailments are by no means exhaustive: maybe other illnesses can be treated with this therapy but, as this is a relatively "young" treatment, we are pioneers, and we need the help of all physicians of good will to definitely establish all the true possibilities of this wonderful therapy. From a practical standpoint, please remember that only Magnesium CHLORIDE has this "cytophilactic" activity, and no other magnesium salt; probably it's a molecular, and not a merely ionic, matter.

The solution to be used is a 2.5% Magnesium Chloride hexahydrate (MgCl2-6H2O) solution (i.e.: 25 grams / 1 liter of water).
Dosages are as follows:
- Adults and children over 5 years old..... 125cc
- 4 year old children...............................100cc
- 3 year old children.................................80cc
- 1-2 year old children..............................60cc
- over 6 months old children.....................30cc
- under 6 months old children...................15cc

These doses must be administered BY MOUTH. The only contraindication to Magnesium Chloride Therapy is a severe renal insufficiency. As the Magnesium Chloride has a mild laxative effect, diarrhea sometimes appears on the first days of therapy, especially when high doses (i.e. three doses a day) are taken; but this is not a reason to stop the therapy. The taste of the solution is not very good ( it has a bitter-saltish flavor) so a little of fruit juice (grapefruit, orange, lemon) can be added to the solution, or it can be even used in the place of water to make the solution itself. For CHRONIC diseases the standard treatment is one dose morning and evening for a long period (several months at least, but it can be continued for years).

In ACUTE diseases the dose is administered every 6 hours (every 3 hours the first two doses if the case is serious); then space every 8 hours and then 12 hours as improvement goes on. After recovery it's better going on with a dose every 12 hours for some days.

As a PREVENTATIVE measure, and as a magnesium supplement, one dose a day can be taken indefinitely. Magnesium Chloride, even if it's an inorganic salt , is very well absorbed and it's a very good supplemental magnesium source.

For INTRAVENOUS injection, the formula is:
Magnesium Chloride hexahydrate....25grams
Distilled Water...............................100cc

Make injections of 10-20cc (very slowly, over 10-20 minutes) once or twice a day. Of course the solution must be sterilized.  This therapy gives very good results also in Veterinary Medicine, at the appropriate dosages depending upon the size and kind of animals.

Raul Vergini, MD - Italy

In view of the importance of magnesium to normal functioning of the enzyme systems and related physiological operations in cancer as well as normal health, I am re-forwarding an interesting article sent to me by an internet associate, found below after the references. Thus goes the exponential relay-cascade of information on the internet.

Let me just briefly lay out the rationale for a three mineral accentuation in cancer therapy: the enzyme degradation of the peri-cellular coating of cancer depends upon the activity of amylase to attack the sialic-acid side chain bearing carbohydrates which give the cancer cell it's strong electro-negative charge which repulses the white blood cells as well as various chemotherapeutic radicals. Calcium ions are specific to the activation of amylase[1]; magnesium ions, besides being involved in hundreds of enzyme processes, activates trypsinogen to trypsin[2], which along with carboxypeptidase and chymotrypsin, sequentially break down the protein backbone of the cancer membrane [3]; chromium-3+ is essential for the fullest activity the protease trypsin, and also for the proper function of the pancreatic endocrine secretion or insulin, which regulates blood sugar but also insures the delivery and concentration of the amino-acids into cellular systems [4]. These amino-acids of course are the basis of protein-enzyme synthesis, both in the pancreas as well as in the cell. And finally, as both a co-factor or co-enzyme and specific anti-neoplastic cytotoxin, the hydrogen cyanide of nitrilosides acts both as a preserver of the enzyme pathways involving cysteine and glutathione[5], but as an accelerator of proteolytic action[6]. The cytotoxic function of nitrilosides in cancer is reviewed in several papers on our web site [7]. Calcium, magnesium and chromium are key in successful nitriloside (Laetrile) and immuno-enzyme cancer therapy. It is also interesting to note the anti-allergic, anti-anaphylactic properties of magnesium noted by Dr. Vergini of Dr.s Delbet's and Neveu's work. Similarly, Dr. Alice Bernheim found calcium effective to the same end. Indeed, her clinical use was most impressive, relieving symptoms in 80% of patients using calcium, vitamin D and hydrochloric acid to aid it's absorption[8]. There are many other protocols of course involved in the succesful enzyme treatment of cancer, and the regimen is individualistic and requires expert monitoring and guidance.


  1. Dixon, M., Webb, E.C., Thorne, C.J.R., and Tipton, K.F., Enzymes, Academic Press, New York, 1979.
  2. Northrop, J.H., Crystalline Enzymes, New York: Columbia University Press, New York, 1939.
  3. Krebs, E.T.,Jr., and Bartlett, C.L., The Pregnancy Toxemias, Medical Record, 162(10):1-12, 1949 also: ; and for relevant comments on the protein structure of the cancer pericellular coating, see the commentary and footnotes in Regelson's article, Have we Found the "Definitive Cancer Biomarker"?, Cancer 76(8):1299-1301; as well as Acevedo, et al., Human Chorionic Gonadotropin-Beta Subunit Gene Expression in Cultured Human Fetal and Cancer Cells of Different Types and Origins, Cancer 76(8):1467-75
  4. Saner,G., Chromium in Nutrition and Disease, Alan Liss, Inc. New York, 1980, p. 16 re: chromium facilitated insulin-amino-acid delivery; p.17, re: optimal action of trypsin with chromium.
  5. Harrison, D.C., The Catalytic Action of Traces of Iron on the Oxidation of Cysteine and Glutathione, Biochemical Journal, 18:1009-1022, 1924.
  6. Mendel, L.B. and Blood, A.F., Some Peculiarities of the Proteolytic Activity of Papain: The Acceleration of Proteolysis by HCN, J.Biol.Chem, Vol. 8:177-213, 1910.
  8. Bernheim, A., A Calcium Regimen in Allergy, Annals of Allergy 22:449-459, September, 1964.; See also Nutrition and Vitamin Therapy, by Michael Lesser, M.D., Bantam Books, 1981, p.110.